Olaf Stapledon in Odd John described the angst of the protagonist, not being able to cope with its diversity and not initially understanding what exactly is that makes him different. At the end he'll gather other like himself on an island, where they will be besieged by the normals, who perceive them as a threat. Richard Matheson, in I Am Legend, reverses the situation imagining the last not mutated human in a world when he is the freak. A chilling read!

Isaac Asimov gifts us withThe Mule, enemy of the Foundation, the poignant image of a telepathic mutant freak in desperate search of love and understanding, who finally uses his powers for conquest and revenge. He compensates his physical weakness and sterility with an enormous willpower (thus the name), but at the end he realizes that his cruelty and hatred did not give him the only thing he could never have.

In more recent times, there's been a series concerning long-lived mutants gifted with psychic powers that evolve from an humanity on the brink of disaster — mutants that, as they search to comprehend and cope with what they are, are perceived as a threat by normal humans, and that are aided by otherworldly beings. This series is Julian May's Galactic Milieu. No sensual hermaphrodites, here, alas. But this series is equally concerned with the development of psychic powers and human potential. Telepathic mutants are born among certain populations all over the Globe, when terrorism and war are threatening to disrupt civilization with nuclear war. Benign observers in a spaceship are observing the Earth in 1945 and are debating whether they should accept humanity in the Galactic Milieu. After Hiroshima they are seriously thinking abandoning humanity to his fate, but a superior incredibly ancient race, to which they defer, votes for giving humanity another chance. The series is mainly narrated through the memories of one of those mutants, Rogi Remillard, whose family is the core of the developing race of mutants. In Intervention, Julian May describes the events leading to the aliens decision to intervene to save humanity, and in the Galactic Milieu trilogy is described the development of the Telepaths in the following centuries, the expansion of humanity in the Galaxy, the attempt of some of those mutants to prevail over the Galactic Milieu itself. It's a very poignant narrative that makes an interesting counterpoint and companion to the Wraeththu series.